Carcinosinum e Chelidonium in carcinoma epatico indotto nei topi

THE JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE

Volume 11, Number 5, 2005, pp. 839–854

© Mary Ann Liebert, Inc.

Efficacy of the Potentized Homeopathic Drug, Carcinosin 200,

Fed Alone and in Combination with Another Drug, Chelidonium

200, in Amelioration of p-Dimethylaminoazobenzene–Induced

Hepatocarcinogenesis in Mice

SURJYO JYOTI BISWAS, Ph.D., SURAJIT PATHAK, M.Sc., NANDINI BHATTACHARJEE, M.Sc.,

JAYANTA KUMAR DAS, Ph.D., and ANISUR RAHMAN KHUDA-BUKHSH, M.Sc., Ph.D.

ABSTRACT

Objectives: This study was conducted to examine whether the potentized homeopathic remedy Carcinosin

200, fed alone and in combination with Chelidonium 200, has differential protective effects against p-dimethylaminoazobenzene

(p-DAB)–induced hepatocarcinogenesis in mice.

Design: Liver tumors were induced in mice through chronic feeding of p-DAB (initiator) and phenobarbital

(PB, promoter). The mice were divided into two subgroups: (1) one was fed potentized Alcohol 200 and served

as controls; and (2) the other was fed Carcinosin 200 alone or in combination with Chelidonium 200 and divided

into several sets. The relative efficacy of the two potentized remedies, alone or in combination, in combating

hepatocarcinogenesis was assessed through several cytogenetical endpoints such as chromosome aberrations,

induction of micronuclei, sperm head anomaly, and mitotic index at several intervals of fixation (days

7, 15, 30, 60, 90, and 120). Several toxicity biomarkers such as acid and alkaline phosphatases, glutamate oxaloacetate

transaminase, glutamate pyruvate transaminase, and lipid peroxidation activity were also assayed in

three organs of treated and control mice. In addition, recovery by the homeopathic drugs, if any, of tissue damage

inflicted because of chronic feeding of p-DAB and PB was also assessed by optical, scanning, and transmission

electron microscopies of liver done at days 60 and 120.

Results: Both Carcinosin 200 and Chelidonium 200 when administered alone show considerable ameliorative

effect against p-DAB–induced hepatocarcinogenesis in mice; but the conjoint feeding of these two drugs

appears to have had a slightly greater protective effect.

Conclusions: These homeopathic remedies have the potential to be used as complementary and alternative

medicine in liver cancer therapy, particularly as supporting palliative measures.

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